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Following the OECD Council decision, the Test Guideline 479 ‘Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells’ was deleted on 2nd April 2014.
Genetic toxicology --- Genotoxicity --- Genotoxicology --- Toxicology --- Biochemical genetics --- Medical genetics --- Carcinogenesis --- Chemical mutagenesis --- Genetic aspects
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Suite à la décision du Conseil de l’OCDE, l’essai 484 "Toxicologie Génétique : Spot Test chez la Souris" a été supprimé le 2 avril 2014.
Genetic Toxicology --- Genotoxicity --- Genotoxicology --- Toxicology --- Biochemical genetics --- Medical genetics --- Carcinogenesis --- Chemical mutagenesis --- Genetic aspects
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Following the OECD Council decision, the Test Guideline 481 ‘Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay’ was deleted on 2nd April 2014.
Genetic toxicology --- Genotoxicity --- Genotoxicology --- Toxicology --- Biochemical genetics --- Medical genetics --- Carcinogenesis --- Chemical mutagenesis --- Genetic aspects
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Following a general update of the Genetic Toxicology TGs in 2015, the present Document was written to provide succinct and useful information to individuals unfamiliar with genetic toxicology testing, as well as experienced individuals wishing to obtain an overview of the recent changes that were made to the TGs during the recent round of revisions. It provides: 1) general background and historical information on the OECD genetic toxicology TGs; 2) a brief overview of the important types of genetic damage evaluated by these tests; 3) a description of the retained TGs; and 4) the issues and changes addressed therein during the revision process.
Genetic toxicology --- Genotoxicity --- Genotoxicology --- Toxicology --- Biochemical genetics --- Medical genetics --- Carcinogenesis --- Chemical mutagenesis --- Genetic aspects --- Genetic toxicology.
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L’essai de mutation létale dominante a pour but de détecter si certaines substances chimiques engendrent des mutations résultant d’aberrations chromosomiques dans les cellules germinales. En outre, l’essai de mutation létale dominante se prête bien à l’évaluation de la génotoxicité, car, malgré des variations entre les espèces, les facteurs du métabolisme in vivo, la pharmacocinétique et les processus de réparation de l’ADN sont actifs et contribuent aux réponses. L’apparition d’une mutation létale dominante à la suite d’une exposition à un produit chimique d’essai indique que cette substance a affecté le tissu germinal de l’animal étudié. La LD 478 initiale a été adoptée en 1984. La présente version modifiée de cette ligne directrice reflète plus de trente années d’expérience de cet essai et tient compte des possibilités de l’intégrer ou de le combiner à d’autres essais de toxicité, notamment pour le développement, la reproduction ou encore des essais de génotoxicité; cependant, étant donné les limitations de l’essai et le grand nombre d’animaux utilisés, cet essai n’a pas vocation à être utilisé en première intention, mais plutôt comme méthode d’essai supplémentaire quand il n’existe pas d’alternative pour satisfaire les exigences réglementaire.
Genetic toxicology. --- Chemical tests and reagents. --- Chemical reagents --- Reagents, Chemical --- Indicators and test-papers --- Genotoxicity --- Genotoxicology --- Toxicology --- Biochemical genetics --- Medical genetics --- Carcinogenesis --- Chemical mutagenesis --- Genetic aspects
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"This book examines the field of bioethics from an international and regional legal perspective. It focuses on major international law documents such as the United Nations Universal Declaration on Bioethics and Human Rights and UNESCO declarations on human cloning and the human genome. Coverage of regional legal instruments includes the Council of Europe Convention on Human Rights and Biomedicine (the Oviedo Convention) and its Protocols on cloning, transplantation, and research with human beings. Work on surrogacy issues by the Hague Conference on Private International Law is also discussed, as are some African regional legal instruments on biosafety, and stem cell research"--Publisher.
Bioethics. --- Science --- Science and ethics --- Biology --- Biomedical ethics --- Life sciences --- Life sciences ethics --- Moral and ethical aspects. --- Moral and ethical aspects --- Bioethics --- Medical laws and legislation --- Medical genetics --- Human experimentation in medicine --- Human rights --- Basic rights --- Civil rights (International law) --- Rights, Human --- Rights of man --- Human security --- Transitional justice --- Truth commissions --- Law, Medical --- Medical personnel --- Medical registration and examination --- Medicine --- Physicians --- Surgeons --- Medical policy --- Medical jurisprudence --- Law and legislation --- Legal status, laws, etc. --- E-books
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